The use of fluid machinery in industry, agriculture, construction, transportation, and all aspects of life has become widespread and plays a vital role. Among these, various types of pumps, particularly centrifugal pumps, are essential and have been consistently studied by researchers. Many efforts have been made to enhance the performance of these pumps. This study analyzes a centrifugal pump to examine the effects of changes in blade thickness, blade rotational velocity, and inlet flow rate, particularly on the pressure distribution within the pump and across the blades. For this purpose, ANSYS Fluent software was utilized for simulation, including the introduction of governing equations and a detailed explanation of the simulation process in the software. The results are presented and discussed through contours and graphs. In total, 15 simulations were conducted on this pump with three variables: blade thickness, impeller rotational velocity, and inlet water velocity.